Search results for "Syndrome Métabolique"
showing 5 items of 5 documents
Metabolic syndrome triggered by high-fructose diet favors choroidal neovascularization and impairs retinal light sensitivity in the rat
2014
Diabetic retinopathy and age-related macular degeneration are the leading causes of blindness in Western populations. Although it is a matter of controversy, large-scale population-based studies have reported increased prevalence of age-related macular degeneration in patients with diabetes or diabetic retinopathy. We hypothesized that metabolic syndrome, one of the major risk factors for type 2 diabetes, would represent a favorable environment for the development of choroidal neovascularization, the main complication of age-related macular degeneration. The fructose-fed rat was used as a model for metabolic syndrome in which choroidal neovascularization was induced by laser photocoagulatio…
Dietary omega 3 fatty acids and metabolic syndrome in the rat retina: consequences on retinal functionality and complications
2014
Dietary omega 3 fatty acids and metabolic syndrome in the rat retina: consequences on retinal functionality and complications. International society for the study of fatty acids and lipids
Lipid and homeostatic alterations in nervous tissues associated with aging and metabolic dysregulations: implication of gut microbiota and autophagy
2020
The retina and the brain are two nervous tissues rich in lipids. Aging and metabolic syndrome (MetS) are associated with functional and physiological alterations of these tissues as well as modifications in the composition of the gut microbiota. The global objective of this thesis work is to understand the lipid and homeostatic alterations in aging and MetS contexts in the retina and the brain. In a first study, we evaluated the impact of the modifications in the composition of the gut microbiota associated with aging on the lipid/fatty acid contents of the liver and the brain (cortex). We showed that colonization of germ-free mice with the gut microbiota of old mice modulated the hepatic e…
Effets du resvératrol et de formulations de micro-nutriments alimentaires sur les fonctions du muscle squelittique chez la souris et sur les cellules…
2012
A concept that has emerged in recent years is the use of micronutrients as therapeutic agents known for their anti-inflammatory, antioxidant, cardio-protective or anticarcinogenic proprieties. In this work, we studied the in vivo and in vitro mechanism of action of resveratrol and two natural formulations, one involved in the antioxidant effects (product "X") and the other (product "Y") involved in the correction of lipid disorders in people affected by metabolic syndrome. We characterized the pro-differentiating effect of a natural polyphenol, resveratrol, on C2C12 skeletal muscle cell line. This study showed that this polyphenol can induce the expression of muscle differentiation factors …
Caractérisation et prévention des conséquences d’un syndrome métabolique dans la rétine
2018
Metabolic syndrome (MetS) results from carbohydrate and lipid disorders that originate from misbalanced energy metabolism. MetS is a risk factor for type 2 diabetes that, in pathophysiological conditions, is characterized by vascular alterations, particularly in the retina, creating the diabetic retinopathy (DR). Despite it presents a barrier limiting the input of blood factors, the retina is under metabolic variations. The consequences of MetS in the retina have not been characterized. MetS would be responsible for the inflammation and microvascular alterations in the retina and could participate to the development of age-related macular degeneration (AMD). A diet rich in omega-3 long chai…